ABSTRACT
A case study of a 41 years old woman with cyclic hypercortisolism is explained. AT the beginning, its manegment was shrinking the tumor, however afterward she needs medical treatment during cycles. The fluctuating clinical and discrepant bioquemical findings make it hard to diagnose. A review of this rare disorder is explained.
Subject(s)
Humans , Adult , Pituitary Neoplasms/complications , Adenoma/complications , Cushing Syndrome/diagnosis , Cushing Syndrome/etiology , Pituitary Neoplasms/diagnosis , Time Factors , Adenoma/diagnosis , Adrenocortical Hyperfunction/diagnosis , Adrenocortical Hyperfunction/etiologyABSTRACT
Silent corticotroph adenomas (SCA) are pituitary adenomas inmunoreactive to ACTH without hormonal overproduction and they form the 3 percent of the pituitary adenomas. Unlike the ademonas that cause the Cushings disease, frequently the SCA are aggressive macroademonas and their clinical expressions are the compromise of nearby structures with or without pituitary apoplexy. Frequently, the treatment chosen is a surgical procedure, albeit the total resection difficulties. The SCA are not diagnosed until an anatomopathological and immunohistochemical study is carried out. In this document, a case study of a woman diagnosed with a clinically silent macrocorticotroph adenomadiscovered by a third nerve palsy is explained.